The Food Safety and Inspection Service (FSIS) is publishing this advance notice of proposed rulemaking (ANPR) to request comments pertaining to the labeling of meat and poultry products comprised of or containing cultured cells derived from animals subject to the Federal Meat Inspection Act (FMIA; 21 U.S.C. 601 et. seq.) or the Poultry Products Inspection Act (PPIA; 21 U.S.C. 451 et seq.). Issues raised in the comments submitted in response to this ANPR will inform future rulemaking to establish labeling requirements for these products. This ANPR also discusses how FSIS will generally evaluate labels for these products if they are submitted before the Agency completes rulemaking. Submit comments on or before November 2, 2021.