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Canada to Implement Proposed MRLs for Pyraziflumid in fruits and nuts

April 21 2022

Health Canada’s PMRA has notified the WTO that proposed MRLs for Pyraziflumid in specific food commodities are to be implemented. Comments from WTO members are due by May 14, 2022.

Health Canada’s PMRA has notified the WTO that proposed MRLs for Pyraziflumid in specific food commodities are to be implemented. Comments from WTO members are due by May 14, 2022.

More than 1,000 pesticides are frequently used to increase yields of cereals, fruits, and vegetables by protecting them against plant diseases caused by pests and pathogens including bacteria, fungi, and viruses. However, residues of those compounds in the environment and food is potentially harmful for human health and a worldwide concern. To ensure food is safe for human consumption, maximum residue limits (MRLs) for pesticides in various commodities have been established in many countries.

In 2018, Pyraziflumid or N-[2-(3,4-difluorophenyl)phenyl]-3 (trifluoromethyl)pyrazine-2-carboxamide); CAS number: 942515-63-1, was discovered as a novel member of succinate dehydrogenase inhibitor fungicide and registered for sale and use in plant cultivation in Japan and South Korea. Three commercial products containing this active ingredient have been launched, for vegetables, fruit crops, and turf, respectively. Nevertheless, there are no MRLs for Pyraziflumid in food in Codex or the European Union. Recently, Health Canada’s Pest Management Regulatory Agency (PMRA) accepted its use for specific foods [2] with a number of MRLS (see proposed MRLs in Table 1).

The Quick Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method is effective for the extraction of most pesticides and is appropriate for Pyraziflumid in crops. Based on its chemical structure, high performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is the best analytical process to give the high accuracy, selectivity, and sensitivity.

Table 1 Proposed MRLs for Pyraziflumid in fruits and nuts.


MRLs (ppm)





Stone fruits


Small fruits vine climbing, except fuzzy kiwifruit                    


Pome fruits


Tree nuts



What do these changes mean?

This update has the potential to affect agricultural producers, food manufacturers, and pesticide manufacturers. Food products destined for Canada, if listed in Table 1, must not have residues of Pyraziflumid exceeding the MRLs. Complying with food safety regulations can be a complex, time-consuming and expensive process. Food producers should seek professional advice.

SGS is committed to keeping you informed of regulation news and developments. Leveraging our global network of laboratories and food experts, SGS provides a comprehensive range of food safety and quality solutions, including analytical tests, audits, certifications, inspections, and technical support. We continually invest in our testing, capability, and state-of-the art technology to help you reduce risk, improve food safety and quality. For furthermore information, please visit our website: www.sgs.com/foodsafety


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Amornpun Dejsiripun

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Tags: food safety news, maximum residue limits (mrls)


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